Up All Night (NBC, Wednesdays, 8pmEST)
After battling and defeating breast cancer and turning in a winning performance in last year's rom-com Going the Distance, audiences have been rooting for Christina Applegate. The Married with Children alum returns to the small screen (after Samantha Who? was taken away from us too soon) as a new Mom, trying to balance her career as a high-power public relations executive, her baby and her drastically altered social life. Arrested Development's Will Arnett (hoping we'll all forget about Running Wilde) plays her stay-at-home husband and Maya Rudolph, riding the wave of success following her role in Bridesmaids, co-stars as Christina's boss/best friend (only in sitcom land can your boss also be your best friend!) The show is produced by Saturday Night Live's Lorne Michaels, so the possible guest star pool is pretty promising. If there's two actors we'd like to see succeed, it's definitely these two!