2. Meredith, Derek, Addison (Grey’s Anatomy) – Meredith Grey has come a long way since her tequila drinking and one-night standing days on the hit show Grey’s Anatomy. During the first two seasons, the perfect primetime couple of Meredith and Derek “McDreamy” Shepherd hit a snag when his ex-wife Addison came back into town to rekindle her lost marriage. After a heartbreaking exchange where Meredith begged Derek to “pick me, choose me, love me,” he decided to stay with his wife much to the chagrin of audiences everywhere. It seemed like both had moved on in their own respective relationships until one instance of your typical sex-in-a-hospital-exam-room-during-a-prom-dance brought the two back to each other. One pair of lost panties later, Addison was on her way to LA to start life anew and the McCouple eventually got to have their happily ever McAfter.